SA 16( SA-16 | SA 16 | SA16 )

Catalog No. M13010 CAS No. 1919884-11-9

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Product Name

SA 16
Note

Research use only, not for human use.
Brief Description

A potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively.
Description

A potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively; blocks glioblastoma multiforme (GBM) proliferation with no toxicity in normal cells, induces GBM apoptosis and inhibits cell migration; exhibits an increased efficacy against glioma stem cells (GSCs), inducing their differentiation and apoptosis.
In Vitro

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In Vivo

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Synonyms

SA-16 | SA 16 | SA16
Pathway

Cell Cycle/DNA Damage
Target

Aurora Kinase
Recptor

Aurora Kinase
Research Area

——
Indication

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CAS Number

1919884-11-9
Formula Weight

606.59
Molecular Formula

C33H24F2N6O4
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(C1=CC=CN(CC2=CC=C(F)C(F)=C2)C1=O)N[C@H](C3=CC=CC=C3)C(NC4=CC5=C(NC(/C5=C\C6=CN=CN6)=O)C=C4)=O
Chemical Name

(R,Z)-N-(2-((3-((1H-imidazol-5-yl)methylene)-2-oxoindolin-5-yl)amino)-2-oxo-1-phenylethyl)-1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

1. Daniele S, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114. 2. Nagashima K, et al. J Biol Chem. 2011 Feb 25;286(8):6433-48.

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